Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 366..946 Replicon plasmid unnamed5
Accession NZ_CP047638
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag GUY22_RS29090 Protein ID WP_001136729.1
Coordinates 366..680 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag GUY22_RS29095 Protein ID WP_000093040.1
Coordinates 668..946 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS29090 366..680 - 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUY22_RS29095 668..946 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
GUY22_RS29100 1288..1506 - 219 WP_002193751.1 TonB family protein -
GUY22_RS29105 1503..1874 - 372 WP_001237044.1 cell envelope integrity protein TolA -
GUY22_RS29110 2148..2393 - 246 WP_159210150.1 hypothetical protein -
GUY22_RS29115 2720..4405 + 1686 WP_032440457.1 cloacin -
GUY22_RS29120 4415..4672 + 258 WP_032440455.1 cloacin -
GUY22_RS29125 4757..4906 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10077 10077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T146999 WP_001136729.1 NZ_CP047638:c680-366 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T146999 NZ_CP062839:c106353-105973 [Escherichia coli]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT146999 WP_000093040.1 NZ_CP047638:c946-668 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT146999 NZ_CP062839:c106574-106353 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References