146993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 51861..52597 Replicon plasmid unnamed1
Accession NZ_CP047634
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag GUY22_RS26450 Protein ID WP_004187044.1
Coordinates 52115..52597 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag GUY22_RS26445 Protein ID WP_003026799.1
Coordinates 51861..52127 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS26430 47333..48727 + 1395 WP_032439652.1 cytosine permease -
GUY22_RS26435 48739..49947 + 1209 WP_032448288.1 imidazolonepropionase -
GUY22_RS26440 49940..50749 + 810 WP_023329017.1 N-formylglutamate deformylase -
GUY22_RS26445 51861..52127 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
GUY22_RS26450 52115..52597 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
GUY22_RS26455 52804..54150 + 1347 WP_077254728.1 ISNCY family transposase -
GUY22_RS26460 54199..54597 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
GUY22_RS29245 54745..54852 - 108 Protein_59 IS3 family transposase -
GUY22_RS26465 54850..55020 - 171 Protein_60 transposase -
GUY22_RS26470 55130..56066 + 937 Protein_61 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / mph(A) / sul1 / qnrB52 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr - 1..174647 174647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T146993 WP_004187044.1 NZ_CP047634:52115-52597 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

>T146993 NZ_CP062838:2664328-2664435 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT146993 WP_003026799.1 NZ_CP047634:51861-52127 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT146993 NZ_CP062838:c2664278-2664215 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References