Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 6953..7596 Replicon plasmid unnamed1
Accession NZ_CP047634
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag GUY22_RS26220 Protein ID WP_016236302.1
Coordinates 7180..7596 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag GUY22_RS26215 Protein ID WP_001261282.1
Coordinates 6953..7183 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS26170 2297..2476 + 180 WP_006788217.1 hypothetical protein -
GUY22_RS26175 2916..3710 - 795 WP_004197635.1 site-specific integrase -
GUY22_RS26185 3908..4924 - 1017 WP_017899884.1 hypothetical protein -
GUY22_RS26190 4935..5249 - 315 WP_053389906.1 hypothetical protein -
GUY22_RS26195 5276..5671 - 396 WP_017899885.1 hypothetical protein -
GUY22_RS26200 5840..6145 - 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB -
GUY22_RS26205 6147..6365 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA -
GUY22_RS26210 6535..6996 - 462 WP_163622397.1 hypothetical protein -
GUY22_RS26215 6953..7183 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GUY22_RS26220 7180..7596 + 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin Toxin
GUY22_RS26225 7670..9232 + 1563 WP_004206609.1 AAA family ATPase -
GUY22_RS26230 9217..10239 + 1023 WP_032439672.1 helicase UvrD -
GUY22_RS26240 10778..11692 + 915 WP_153378766.1 HNH endonuclease -
GUY22_RS26245 11878..12228 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / mph(A) / sul1 / qnrB52 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr - 1..174647 174647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.55 Da        Isoelectric Point: 7.1084

>T146992 WP_016236302.1 NZ_CP047634:7180-7596 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T146992 NZ_CP062838:2663793-2663900 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT146992 WP_001261282.1 NZ_CP047634:6953-7183 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT146992 NZ_CP062838:c2663746-2663680 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References