146986

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4010724..4011343 Replicon chromosome
Accession NZ_CP047633
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GUY22_RS19850 Protein ID WP_002892050.1
Coordinates 4011125..4011343 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GUY22_RS19845 Protein ID WP_002892066.1
Coordinates 4010724..4011098 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS19835 4005876..4007069 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GUY22_RS19840 4007092..4010238 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GUY22_RS19845 4010724..4011098 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GUY22_RS19850 4011125..4011343 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GUY22_RS19855 4011502..4012068 + 567 WP_002892030.1 maltose O-acetyltransferase -
GUY22_RS19860 4012040..4012180 - 141 WP_004147370.1 hypothetical protein -
GUY22_RS19865 4012201..4012671 + 471 WP_002892026.1 YlaC family protein -
GUY22_RS19870 4012646..4014097 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GUY22_RS19875 4014198..4014896 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GUY22_RS19880 4014893..4015033 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GUY22_RS19885 4015033..4015296 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T146986 WP_002892050.1 NZ_CP047633:4011125-4011343 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T146986 NZ_CP062838:1049938-1050273 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACGCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT146986 WP_002892066.1 NZ_CP047633:4010724-4011098 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT146986 NZ_CP062838:1049690-1049938 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References