Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805498..806155 Replicon chromosome
Accession NZ_CP047633
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GUY22_RS04050 Protein ID WP_002916310.1
Coordinates 805745..806155 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GUY22_RS04045 Protein ID WP_002916312.1
Coordinates 805498..805764 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS04020 800654..802087 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GUY22_RS04025 802206..802934 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GUY22_RS04030 802984..803295 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GUY22_RS04035 803459..804118 + 660 WP_002916317.1 hemolysin III family protein -
GUY22_RS04040 804269..805252 - 984 WP_163621823.1 tRNA-modifying protein YgfZ -
GUY22_RS04045 805498..805764 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GUY22_RS04050 805745..806155 + 411 WP_002916310.1 protein YgfX Toxin
GUY22_RS04055 806162..806683 - 522 WP_087638529.1 flavodoxin FldB -
GUY22_RS04060 806784..807680 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GUY22_RS04065 807703..808416 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GUY22_RS04070 808422..810155 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T146976 WP_002916310.1 NZ_CP047633:805745-806155 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T146976 NZ_CP062837:94743-95141 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT146976 WP_002916312.1 NZ_CP047633:805498-805764 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146976 NZ_CP062837:94516-94743 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References