Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1252119..1252566 Replicon chromosome
Accession NZ_CP047630
Organism Lactococcus raffinolactis strain Lr_18_12S

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GU333_RS06310 Protein ID WP_082785381.1
Coordinates 1252300..1252566 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A5SDT8
Locus tag GU333_RS06305 Protein ID WP_061774359.1
Coordinates 1252119..1252310 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GU333_RS06295 1247344..1249299 - 1956 WP_167840046.1 DNA topoisomerase IV subunit B -
GU333_RS06300 1249700..1251853 - 2154 WP_167842201.1 type I DNA topoisomerase -
GU333_RS06305 1252119..1252310 + 192 WP_061774359.1 hypothetical protein Antitoxin
GU333_RS06310 1252300..1252566 + 267 WP_082785381.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GU333_RS06315 1252635..1253498 - 864 WP_167842202.1 ROK family protein -
GU333_RS06320 1253504..1254928 - 1425 WP_167842203.1 glycoside hydrolase family 1 protein -
GU333_RS06325 1255142..1255837 - 696 WP_061774362.1 LrgB family protein -
GU333_RS06330 1255834..1256196 - 363 WP_061774363.1 CidA/LrgA family protein -
GU333_RS06335 1256324..1257535 - 1212 WP_096040552.1 CapA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-87)

Antitoxin

Protein of unknown function DUF6290

(2-37)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10572.25 Da        Isoelectric Point: 10.0256

>T146973 WP_082785381.1 NZ_CP047630:1252300-1252566 [Lactococcus raffinolactis]
VTYDFIPSPKFNRQFRILDKFTQKCIQNYINNVILKADNPHNHGKQLVGDLAVLWRYRIGDYRLIVTIQDNELMVLALQI
NHRRDIYR

Download         Length: 267 bp

>T146973 NZ_CP062836:67866-68018 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7328.24 Da        Isoelectric Point: 4.1683

>AT146973 WP_061774359.1 NZ_CP047630:1252119-1252310 [Lactococcus raffinolactis]
MAKFEGLSLSESIKRTMVEKYENDYDLKVAETSIAEFQKYIISDKPVQSWEDLQPELGLDRDV

Download         Length: 192 bp

>AT146973 NZ_CP062836:c67811-67754 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5SDT8

References