Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1149678..1150125 Replicon chromosome
Accession NZ_CP047616
Organism Lactococcus raffinolactis strain Lr_19_5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GU336_RS05685 Protein ID WP_138491389.1
Coordinates 1149678..1149944 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A5SDT8
Locus tag GU336_RS05690 Protein ID WP_061774359.1
Coordinates 1149934..1150125 (-) Length 64 a.a.

Genomic Context

GU336_RS05660GU336_RS05665GU336_RS05670GU336_RS05675GU336_RS05680GU336_RS05695GU336_RS05700GU336_RS05685GU336_RS05690
Location: 1144708..1145919 (1212 bp)
Type: Others
Protein ID: WP_096040552.1
Location: 1146047..1146409 (363 bp)
Type: Others
Protein ID: WP_061774363.1
Location: 1146406..1147101 (696 bp)
Type: Others
Protein ID: WP_061774362.1
Location: 1147316..1148740 (1425 bp)
Type: Others
Protein ID: Protein_1076
Location: 1148746..1149609 (864 bp)
Type: Others
Protein ID: WP_061774360.1
Location: 1150391..1152544 (2154 bp)
Type: Others
Protein ID: WP_167838662.1
Location: 1152749..1153699 (951 bp)
Type: Others
Protein ID: WP_167838195.1
Location: 1149678..1149944 (267 bp)
Type: Toxin
Protein ID: WP_138491389.1
Location: 1149934..1150125 (192 bp)
Type: Antitoxin
Protein ID: WP_061774359.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GU336_RS056601144708..1145919+1212WP_096040552.1CapA family protein-
GU336_RS056651146047..1146409+363WP_061774363.1CidA/LrgA family protein-
GU336_RS056701146406..1147101+696WP_061774362.1LrgB family protein-
GU336_RS056751147316..1148740+1425Protein_1076glycoside hydrolase family 1 protein-
GU336_RS056801148746..1149609+864WP_061774360.1ROK family protein-
GU336_RS056851149678..1149944-267WP_138491389.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GU336_RS056901149934..1150125-192WP_061774359.1hypothetical proteinAntitoxin
GU336_RS056951150391..1152544+2154WP_167838662.1type I DNA topoisomerase-
GU336_RS057001152749..1153699+951WP_167838195.1IS30 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-87)

Antitoxin

Protein of unknown function DUF6290

(2-37)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10586.30 Da        Isoelectric Point: 10.0256

>T146970 WP_138491389.1 NZ_CP047616:c1149944-1149678 [Lactococcus raffinolactis]
VTYDFIPSPKFNRQFRILDKFTQKCIQNYINNVILKADNPHNHGKQLVGDLAVLWRYRIGDYRLIVMIQDNELMVPALQI
NHRRDIYR

Download         Length: 267 bp

>T146970 NZ_CP062832:c4269317-4269144 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7328.24 Da        Isoelectric Point: 4.1683

>AT146970 WP_061774359.1 NZ_CP047616:c1150125-1149934 [Lactococcus raffinolactis]
MAKFEGLSLSESIKRTMVEKYENDYDLKVAETSIAEFQKYIISDKPVQSWEDLQPELGLDRDV

Download         Length: 192 bp

>AT146970 NZ_CP062832:c4269641-4269345 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2A5SDT8

References