Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4433899..4434415 Replicon chromosome
Accession NZ_CP047606
Organism Citrobacter sp. LUTT5

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag GUC46_RS21145 Protein ID WP_003839578.1
Coordinates 4433899..4434183 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GUC46_RS21150 Protein ID WP_061548940.1
Coordinates 4434173..4434415 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC46_RS21130 4430224..4430808 + 585 WP_003844920.1 fructose PTS transporter subunit IIA -
GUC46_RS21135 4431186..4433324 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
GUC46_RS21140 4433431..4433895 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GUC46_RS21145 4433899..4434183 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUC46_RS21150 4434173..4434415 - 243 WP_061548940.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GUC46_RS21155 4434493..4436406 - 1914 WP_061548941.1 BglG family transcription antiterminator -
GUC46_RS21160 4436428..4437168 - 741 WP_003025772.1 KDGP aldolase family protein -
GUC46_RS21165 4437165..4438283 - 1119 WP_130715212.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GUC46_RS21170 4438267..4439400 - 1134 WP_049002371.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T146923 WP_003839578.1 NZ_CP047606:c4434183-4433899 [Citrobacter sp. LUTT5]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T146923 NZ_CP062826:194912-195019 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.32 Da        Isoelectric Point: 5.0651

>AT146923 WP_061548940.1 NZ_CP047606:c4434415-4434173 [Citrobacter sp. LUTT5]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLAGPQKGIKVSLDDL

Download         Length: 243 bp

>AT146923 NZ_CP062826:c194863-194800 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure

References