146921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3887017..3887696 Replicon chromosome
Accession NZ_CP047606
Organism Citrobacter sp. LUTT5

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag GUC46_RS18725 Protein ID WP_003031349.1
Coordinates 3887355..3887696 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag GUC46_RS18720 Protein ID WP_003031347.1
Coordinates 3887017..3887334 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC46_RS18695 3884152..3885312 - 1161 WP_049015173.1 IS30 family transposase -
GUC46_RS18700 3885611..3885802 + 192 Protein_3661 DUF905 family protein -
GUC46_RS18705 3885816..3886277 + 462 WP_003031344.1 antirestriction protein -
GUC46_RS18710 3886293..3886769 + 477 WP_003031345.1 RadC family protein -
GUC46_RS18715 3886778..3886999 + 222 WP_003031346.1 DUF987 domain-containing protein -
GUC46_RS18720 3887017..3887334 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GUC46_RS18725 3887355..3887696 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
GUC46_RS18735 3888326..3888790 - 465 WP_032941277.1 isoprenylcysteine carboxylmethyltransferase family protein -
GUC46_RS18740 3888983..3890431 - 1449 WP_160180603.1 EAL domain-containing protein -
GUC46_RS18745 3890773..3891246 - 474 WP_003838775.1 hypothetical protein -
GUC46_RS18750 3891221..3891952 - 732 WP_044714364.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3884152..3885312 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T146921 WP_003031349.1 NZ_CP047606:3887355-3887696 [Citrobacter sp. LUTT5]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T146921 NZ_CP062825:15459-15740 [Escherichia coli O167:H26]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT146921 WP_003031347.1 NZ_CP047606:3887017-3887334 [Citrobacter sp. LUTT5]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT146921 NZ_CP062825:15193-15462 [Escherichia coli O167:H26]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References