Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3631446..3632066 Replicon chromosome
Accession NZ_CP047606
Organism Citrobacter sp. LUTT5

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GUC46_RS17515 Protein ID WP_002892050.1
Coordinates 3631848..3632066 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GUC46_RS17510 Protein ID WP_003021733.1
Coordinates 3631446..3631820 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC46_RS17500 3626592..3627785 + 1194 WP_088902653.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GUC46_RS17505 3627808..3630957 + 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
GUC46_RS17510 3631446..3631820 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
GUC46_RS17515 3631848..3632066 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GUC46_RS17520 3632248..3632799 + 552 WP_003021728.1 maltose O-acetyltransferase -
GUC46_RS17525 3632916..3633386 + 471 WP_003021724.1 YlaC family protein -
GUC46_RS17530 3633465..3633605 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GUC46_RS17535 3633607..3633867 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
GUC46_RS17540 3634056..3635609 + 1554 WP_003835927.1 EAL domain-containing protein -
GUC46_RS17545 3635661..3636014 - 354 WP_003831033.1 DUF1428 family protein -
GUC46_RS17550 3636079..3636708 - 630 WP_130714915.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T146920 WP_002892050.1 NZ_CP047606:3631848-3632066 [Citrobacter sp. LUTT5]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T146920 NZ_CP062824:4198180-4198491 [Escherichia coli O167:H26]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT146920 WP_003021733.1 NZ_CP047606:3631446-3631820 [Citrobacter sp. LUTT5]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146920 NZ_CP062824:4198488-4198907 [Escherichia coli O167:H26]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAGCAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References