Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884003..884657 Replicon chromosome
Accession NZ_CP047606
Organism Citrobacter sp. LUTT5

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag GUC46_RS04205 Protein ID WP_003026936.1
Coordinates 884250..884657 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag GUC46_RS04200 Protein ID WP_003026938.1
Coordinates 884003..884269 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC46_RS04175 879202..880635 - 1434 WP_087879267.1 6-phospho-beta-glucosidase BglA -
GUC46_RS04180 880756..881484 - 729 WP_160180771.1 MurR/RpiR family transcriptional regulator -
GUC46_RS04185 881537..881848 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
GUC46_RS04190 882011..882670 + 660 WP_160179798.1 hemolysin III family protein -
GUC46_RS04195 882764..883744 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
GUC46_RS04200 884003..884269 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
GUC46_RS04205 884250..884657 + 408 WP_003026936.1 protein YgfX Toxin
GUC46_RS04210 884702..885223 - 522 WP_003026933.1 flavodoxin FldB -
GUC46_RS04215 885337..886233 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
GUC46_RS04220 886257..886970 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GUC46_RS04225 886976..888709 + 1734 WP_048232743.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T146910 WP_003026936.1 NZ_CP047606:884250-884657 [Citrobacter sp. LUTT5]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T146910 NZ_CP062824:c2475336-2474986 [Escherichia coli O167:H26]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT146910 WP_003026938.1 NZ_CP047606:884003-884269 [Citrobacter sp. LUTT5]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146910 NZ_CP062824:c2475581-2475330 [Escherichia coli O167:H26]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References