Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5726290..5726900 Replicon chromosome
Accession NZ_CP047604
Organism Klebsiella sp. MPUS7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GUC22_RS26790 Protein ID WP_098363641.1
Coordinates 5726290..5726664 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GUC22_RS26795 Protein ID WP_077265771.1
Coordinates 5726661..5726900 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC22_RS26775 5723445..5724347 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
GUC22_RS26780 5724344..5724979 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
GUC22_RS26785 5725323..5726252 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
GUC22_RS26790 5726290..5726664 - 375 WP_098363641.1 type II toxin-antitoxin system VapC family toxin Toxin
GUC22_RS26795 5726661..5726900 - 240 WP_077265771.1 ribbon-helix-helix domain-containing protein Antitoxin
GUC22_RS26800 5727106..5728023 + 918 WP_024360706.1 alpha/beta hydrolase -
GUC22_RS26805 5728041..5728982 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
GUC22_RS26810 5729027..5729464 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
GUC22_RS26815 5729461..5730321 - 861 WP_024360708.1 virulence factor BrkB family protein -
GUC22_RS26820 5730315..5730914 - 600 WP_024360709.1 glucose-1-phosphatase -
GUC22_RS26825 5731044..5731829 - 786 WP_064342034.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14081.36 Da        Isoelectric Point: 8.4571

>T146909 WP_098363641.1 NZ_CP047604:c5726664-5726290 [Klebsiella sp. MPUS7]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWTEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T146909 NZ_CP062824:c2463805-2463515 [Escherichia coli O167:H26]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9307.51 Da        Isoelectric Point: 4.3253

>AT146909 WP_077265771.1 NZ_CP047604:c5726900-5726661 [Klebsiella sp. MPUS7]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEEGVEFERKLREEWQ

Download         Length: 240 bp

>AT146909 NZ_CP062824:c2464037-2463795 [Escherichia coli O167:H26]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCTACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References