Detailed information of TA system TA146907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4623883..4624702
• Replicon: chromosome
• Accession: NZ_CP047604
• Organism: Klebsiella sp. MPUS7

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: GUC22_RS21595
• Protein ID: WP_004132607.1
• Coordinates: 4624445..4624702 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: GUC22_RS21590
• Protein ID: WP_004132606.1
• Coordinates: 4623883..4624434 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUC22_RS21575	4619274..4620671	+	1398	WP_024359118.1	MFS transporter	-
GUC22_RS21580	4620795..4622135	+	1341	WP_024359119.1	carbohydrate porin	-
GUC22_RS21585	4622237..4623865	-	1629	WP_154955480.1	SAM-dependent methyltransferase	-
GUC22_RS21590	4623883..4624434	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
GUC22_RS21595	4624445..4624702	-	258	WP_004132607.1	YjhX family toxin	Toxin
GUC22_RS21600	4625286..4626470	+	1185	WP_049085652.1	mannonate dehydratase	-
GUC22_RS21605	4626547..4628022	+	1476	WP_160183766.1	fructuronate reductase	-
GUC22_RS21610	4628159..4628935	+	777	WP_116944170.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T146907 WP_004132607.1 NZ_CP047604:c4624702-4624445 [Klebsiella sp. MPUS7]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T146907 NZ_CP062824:c2003979-2003611 [Escherichia coli O167:H26]
ATGAAAAATCCACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTT
ACCTCTCCGGTACAAGCACCATATTTGACTACGACAGACATTCTTCAAGCTAGGAAAGCGTGCGGGCTGATGAGCCGGTG
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCAAGGCTGTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT146907 WP_004132606.1 NZ_CP047604:c4624434-4623883 [Klebsiella sp. MPUS7]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT146907 NZ_CP062824:c2004356-2004000 [Escherichia coli O167:H26]
ATGAACAATCACTCAGAATCTGGTGACAAGCCGGAGAATCCAGCCTGCCAGCAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGTCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACGATGACGCGCTGCACCTGGATCAGGTCTTTCCGTTGATACTCAAACAACTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTTCCCGGCATCAGCACTGCGTCACGCTATATCACAACGGACTCACGTGCGAAGCCGATACCCTTGGTAGTTGCGG
CTACGTATACATCGCCATTTATCCCACTCAACGCTAA