Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4399339..4399958 Replicon chromosome
Accession NZ_CP047604
Organism Klebsiella sp. MPUS7

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag GUC22_RS20530 Protein ID WP_004099646.1
Coordinates 4399740..4399958 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag GUC22_RS20525 Protein ID WP_004129911.1
Coordinates 4399339..4399713 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC22_RS20515 4394508..4395701 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GUC22_RS20520 4395724..4398870 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit -
GUC22_RS20525 4399339..4399713 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
GUC22_RS20530 4399740..4399958 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
GUC22_RS20535 4400120..4400686 + 567 WP_004136050.1 maltose O-acetyltransferase -
GUC22_RS20540 4400813..4401283 + 471 WP_004136048.1 YlaC family protein -
GUC22_RS20545 4401258..4402712 - 1455 WP_049131897.1 PLP-dependent aminotransferase family protein -
GUC22_RS20550 4402813..4403511 + 699 WP_004136044.1 GNAT family N-acetyltransferase -
GUC22_RS20555 4403508..4403648 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GUC22_RS20560 4403648..4403911 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T146906 WP_004099646.1 NZ_CP047604:4399740-4399958 [Klebsiella sp. MPUS7]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T146906 NZ_CP062824:1792929-1793147 [Escherichia coli O167:H26]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT146906 WP_004129911.1 NZ_CP047604:4399339-4399713 [Klebsiella sp. MPUS7]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT146906 NZ_CP062824:1792529-1792903 [Escherichia coli O167:H26]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References