Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4782097..4782613 Replicon chromosome
Accession NZ_CP047595
Organism Klebsiella pneumoniae strain Kpn 1693

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag GTK25_RS22810 Protein ID WP_004178374.1
Coordinates 4782097..4782381 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GTK25_RS22815 Protein ID WP_002886901.1
Coordinates 4782371..4782613 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK25_RS22785 (4777493) 4777493..4777756 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
GTK25_RS22790 (4777886) 4777886..4778059 + 174 WP_041169004.1 hypothetical protein -
GTK25_RS22795 (4778062) 4778062..4778805 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GTK25_RS22800 (4779162) 4779162..4781300 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
GTK25_RS22805 (4781629) 4781629..4782093 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GTK25_RS22810 (4782097) 4782097..4782381 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTK25_RS22815 (4782371) 4782371..4782613 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTK25_RS22820 (4782691) 4782691..4784601 - 1911 WP_094966167.1 PRD domain-containing protein -
GTK25_RS22825 (4784624) 4784624..4785778 - 1155 WP_012737230.1 lactonase family protein -
GTK25_RS22830 (4785845) 4785845..4786585 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T146856 WP_004178374.1 NZ_CP047595:c4782381-4782097 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T146856 NZ_CP062811:c4505706-4505533 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTATCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT146856 WP_002886901.1 NZ_CP047595:c4782613-4782371 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT146856 NZ_CP062811:c4506030-4505734 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References