Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2198098..2199686 Replicon chromosome
Accession NZ_CP047594
Organism Escherichia coli strain LD27-1

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag GUU88_RS10650 Protein ID WP_001125439.1
Coordinates 2198364..2199686 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GUU88_RS10645 Protein ID WP_001301023.1
Coordinates 2198098..2198364 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU88_RS10640 2194199..2197875 + 3677 Protein_2076 autotransporter barrel domain-containing lipoprotein -
GUU88_RS10645 2198098..2198364 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GUU88_RS10650 2198364..2199686 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
GUU88_RS10655 2199996..2201224 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
GUU88_RS10660 2201236..2202984 - 1749 Protein_2080 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2172331..2202984 30653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T146826 WP_001125439.1 NZ_CP047594:2198364-2199686 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T146826 NZ_CP062804:118392-118670 [Cupriavidus basilensis]
ATGATCCAGTCGTTCAAATGCGAAGACACTGCAGCGTTGTTCTCAGGCCGGCGCGTTCCGCGATTCGCCAATATCAGGGC
AGCGGCAGAACGCAAGCTGGAGATGCTTGCGGTTGCTGCCTCGCTCGACTTCCTGCGGTCCCCGCCTGGCAACCGGCTCG
AAGTGCTGGGAGGCGACCGCAAAGGGCAGCACAGCATTCGCATCAACGATCGGTGGCGAGTGTGCTTCGTTTGGACGCCC
GATGGCCCGCAGGCCGTCGAGATCGTGGACTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT146826 WP_001301023.1 NZ_CP047594:2198098-2198364 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT146826 NZ_CP062804:118683-118997 [Cupriavidus basilensis]
ATGGCCCGCTTCCATAACGGCATGCGACCGGTCCATCCCGGCGAAATCCTCCGCGAGGAGTTTCTCGTCCCGCTTGGCAT
GAGCGCCAATGCGCTCGCCGTGGCGCTGCATGTCACCGCGGCTCGCATCAACGACATCGTGCGCGAGCGCCGGGGCATTA
CGCCGGACACTGCCATGCGGCTGGCTCGCTACTTTGGCGGCGACGCCGAGTCCTGGCTCAACCTGCAGCAGTCTTATGAC
CTGAAAGTGGCTCAGCGCGAACACGGCAAGGAGATCGCGGCCCAGATCGCGCCACGCGACCTGGAAGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References