Detailed information of TA system TA146811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5559949..5561207
• Replicon: chromosome
• Accession: NZ_CP047592
• Organism: Pseudomonas aeruginosa strain INP-43

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: GQS72_RS25650
• Protein ID: WP_003112528.1
• Coordinates: 5559949..5560704 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: GQS72_RS25655
• Protein ID: WP_003086329.1
• Coordinates: 5560839..5561207 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQS72_RS25640	5555121..5557664	+	2544	WP_070654225.1	acyl-homoserine-lactone acylase QuiP	-
GQS72_RS25645	5557819..5559180	-	1362	WP_073652223.1	DNA recombination protein RmuC	-
GQS72_RS25650	5559949..5560704	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
GQS72_RS25655	5560839..5561207	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
GQS72_RS25660	5561280..5562566	-	1287	WP_160189216.1	FAD-binding oxidoreductase	-
GQS72_RS25665	5562622..5564211	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
GQS72_RS25670	5564290..5564766	+	477	WP_004353334.1	elongation factor GreAB	-
GQS72_RS29500	5564769..5565044	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T146811 WP_003112528.1 NZ_CP047592:c5560704-5559949 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T146811 NZ_CP062789:1816320-1816718 [Janibacter indicus]
GTGACGCTCGTCGACACCTCCGTGTGGGTCGAGTACCTGCGCGGCACCGACTCGCCCTCCACCCGATATGTGCGGGAGCG
TCTCGGCAGCGACCTGTTCACCACCGAGCCCGTGCTCATGGAGCTGCTGGCCGGGGCTCGTCCTGGGGCGTCGACGGCTC
GCCTCGAGCGGCTGCTCCTCAGTCAGAGCTGGGCGCGCCTGGAGTCGTCGCTCGACCATCGAGGTGCGGTTGACGTCTTC
CACGCCTGCCGCTCGGACGGGCATCCCGTCCGGTCGCTCAACGATTGCCTCATCGCTGCCGCGGCGCTGCGGGTAGGCCT
CCCGGTGGCCCATCGCGACGCCGACTTCGAGCGCATCGCAGCAGTCACCGGCCTCACCGTCGTCGACCTGCGTGGGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT146811 WP_003086329.1 NZ_CP047592:c5561207-5560839 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT146811 NZ_CP062789:1816114-1816323 [Janibacter indicus]
ATGGGTCGCACCAACATCGAGATCGACGACGACCTCATCGCCGAGGCCATGCGTCGCTATGGGCTCGCGACCAAGCGTGA
GGCGGTCGACTTCGCCCTGCGACGTCTCGTGGGCCCGGTCATGACGCGCGAGGAGATGCTCGCGATGGAGGGCAGTGGCT
GGGACGGCGACCTCGACCAGGTGAGGTCCGACCCGGTGGAGCCGGTGTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7