Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4647166..4648387 Replicon chromosome
Accession NZ_CP047592
Organism Pseudomonas aeruginosa strain INP-43

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GQS72_RS21400 Protein ID WP_003114949.1
Coordinates 4647809..4648387 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GQS72_RS21395 Protein ID WP_003088112.1
Coordinates 4647166..4647720 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQS72_RS21370 4642734..4643285 + 552 WP_004343115.1 XRE family transcriptional regulator -
GQS72_RS21375 4643282..4643680 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
GQS72_RS21380 4643693..4644016 - 324 WP_003102734.1 multidrug efflux SMR transporter -
GQS72_RS21385 4644347..4644808 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
GQS72_RS21390 4644813..4647008 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GQS72_RS21395 4647166..4647720 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
GQS72_RS21400 4647809..4648387 + 579 WP_003114949.1 HD domain-containing protein Toxin
GQS72_RS21405 4648495..4649682 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
GQS72_RS21410 4649672..4651843 - 2172 WP_160189183.1 type I secretion system permease/ATPase -
GQS72_RS21415 4651833..4653110 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T146810 WP_003114949.1 NZ_CP047592:4647809-4648387 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T146810 NZ_CP062788:c691093-690917 [Aestuariispira ectoiniformans]
GTGATTAAGCTGTTGGAACGGGATGGTTGGTATCATGTCAGAACGAGAGGCGATCACCACCATTTCAAACATCCGACAAA
ACCGGGAAAGGTAACGGTTCCCCACCCGAATAAATCACTGAAAAAGGGAACCTTGCGCAGCATCGAACGTCAGGCTGGAA
TTCGCCTCCAGCCTTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT146810 WP_003088112.1 NZ_CP047592:4647166-4647720 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT146810 NZ_CP062788:c690905-690480 [Aestuariispira ectoiniformans]
ATGAAACGCTTTTTCCCCGCCGTCGTAGAAACCGACGATGAACCGGGATACTCTGTCTTCTTCCCGGATTTTCCCGGCTG
CACAAGTGCCGGTGAGACAATCGAGGAGGCCGTACAAGGCGCCAAGGAGGCCCTGGCGGGACATATCGAATTGATGGTTG
AGGATGGTGATGCAATCCCAGCCCCCAGCAATTTGGATGACCTTGTTTTCGATGAAGACATTTCTGTTGAGCTTGTGGTT
CTGGTCGACGCAACAACCCCTGGCAAAAAACAGCGATATAATGTGACCTTGGACTCCAGTCTCGTCGAGGCCATCGATCA
CGTATCACCCAACAGATCCGCTTTCCTGGAACAGGCAGCACGTGAAAAACTGCGCCATGACAGGGCGCCGGTTAGGCCCG
AACGCCCCGTTCATCCAATACTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References