Detailed information of TA system TA146805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4008273..4009844
• Replicon: chromosome
• Accession: NZ_CP047589
• Organism: Proteus mirabilis strain SNYG35

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GT733_RS18320
• Protein ID: WP_036908598.1
• Coordinates: 4008273..4009586 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: GT733_RS18325
• Protein ID: WP_004249771.1
• Coordinates: 4009587..4009844 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GT733_RS18300 (GT733_18375)	4003442..4004245	+	804	WP_004249775.1	energy transducer TonB	-
GT733_RS18305 (GT733_18380)	4004299..4006260	-	1962	WP_012368635.1	insecticidal delta-endotoxin Cry8Ea1 family protein	-
GT733_RS18310 (GT733_18385)	4006292..4007221	-	930	WP_004246518.1	metallophosphoesterase	-
GT733_RS18315 (GT733_18390)	4007406..4007870	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
GT733_RS18320 (GT733_18395)	4008273..4009586	-	1314	WP_036908598.1	type II toxin-antitoxin system HipA family toxin	Toxin
GT733_RS18325 (GT733_18400)	4009587..4009844	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
GT733_RS18330 (GT733_18405)	4009993..4011357	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GT733_RS18335 (GT733_18410)	4011495..4013135	-	1641	WP_004246512.1	membrane protein insertase YidC	-
GT733_RS18340 (GT733_18415)	4013138..4013398	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
GT733_RS18345 (GT733_18420)	4013362..4013721	-	360	WP_004246510.1	ribonuclease P protein component	-
GT733_RS18350 (GT733_18425)	4013739..4013882	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49669.80 Da
• Isoelectric Point: 6.6588

>T146805 WP_036908598.1 NZ_CP047589:c4009586-4008273 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T146805 NZ_CP062784:c27262-27080 [Escherichia coli O157:H7]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT146805 WP_004249771.1 NZ_CP047589:c4009844-4009587 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT146805 NZ_CP062784:c27055-26618 [Escherichia coli O157:H7]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAAGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATCGTGG
AAGAAATGGTTTTAAGTGGCTCTTATTCTGTTGACGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAGAGAAAGTGGCGGTGTTTATAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAACTTTCATATAAATGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9