Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 126002..126549 Replicon plasmid p94EC-1
Accession NZ_CP047577
Organism Escherichia coli strain 94EC

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GUJ28_RS23800 Protein ID WP_042033558.1
Coordinates 126268..126549 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag GUJ28_RS23795 Protein ID WP_000079941.1
Coordinates 126002..126271 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUJ28_RS23785 122781..124055 - 1275 WP_000489607.1 HlyD family secretion protein -
GUJ28_RS23795 126002..126271 + 270 WP_000079941.1 hypothetical protein Antitoxin
GUJ28_RS23800 126268..126549 + 282 WP_042033558.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUJ28_RS23805 126595..127443 + 849 WP_001058005.1 3'-5' exonuclease -
GUJ28_RS23810 127560..128042 + 483 WP_001311056.1 hypothetical protein -
GUJ28_RS23815 128344..128691 + 348 WP_000142437.1 hypothetical protein -
GUJ28_RS23820 129077..130108 - 1032 WP_001752311.1 IS630-like element ISEc33 family transposase -
GUJ28_RS23825 130405..131439 + 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / sitABCD iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..178137 178137
- inside IScluster/Tn - - 124252..132661 8409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10888.53 Da        Isoelectric Point: 8.4615

>T146790 WP_042033558.1 NZ_CP047577:126268-126549 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRGLHTVQKWP

Download         Length: 282 bp

>T146790 NZ_CP062782:3195422-3195529 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT146790 WP_000079941.1 NZ_CP047577:126002-126271 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT146790 NZ_CP062782:c3195374-3195315 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References