Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3986389..3986984 Replicon chromosome
Accession NZ_CP047571
Organism Escherichia coli strain 2EC1

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag GTQ78_RS19290 Protein ID WP_160177646.1
Coordinates 3986389..3986739 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag GTQ78_RS19295 Protein ID WP_001223208.1
Coordinates 3986733..3986984 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTQ78_RS19270 3981838..3982860 - 1023 WP_001353963.1 ABC transporter permease -
GTQ78_RS19275 3982874..3984376 - 1503 WP_160177645.1 sugar ABC transporter ATP-binding protein -
GTQ78_RS19280 3984516..3985472 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
GTQ78_RS19285 3985782..3986312 + 531 WP_000055072.1 inorganic diphosphatase -
GTQ78_RS19290 3986389..3986739 - 351 WP_160177646.1 endoribonuclease toxin ChpB Toxin
GTQ78_RS19295 3986733..3986984 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
GTQ78_RS19300 3987196..3987537 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
GTQ78_RS19305 3987540..3991319 - 3780 WP_160177647.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12497.42 Da        Isoelectric Point: 5.6150

>T146748 WP_160177646.1 NZ_CP047571:c3986739-3986389 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADDVVEEALLRLQAVVE

Download         Length: 351 bp

>T146748 NZ_CP062780:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT146748 WP_001223208.1 NZ_CP047571:c3986984-3986733 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT146748 NZ_CP062780:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References