Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4575096..4575700 Replicon chromosome
Accession NZ_CP047570
Organism Enterobacter hormaechei strain F2

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag GTQ93_RS21740 Protein ID WP_071788668.1
Coordinates 4575096..4575281 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag GTQ93_RS21745 Protein ID WP_023295606.1
Coordinates 4575296..4575700 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTQ93_RS21725 4570415..4572253 + 1839 WP_141414792.1 selenocysteine-specific translation elongation factor -
GTQ93_RS21730 4572257..4573141 - 885 WP_015572761.1 ROK family protein -
GTQ93_RS21735 4573308..4574846 + 1539 WP_033488028.1 aldehyde dehydrogenase AldB -
GTQ93_RS21740 4575096..4575281 + 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
GTQ93_RS21745 4575296..4575700 + 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTQ93_RS21750 4575756..4577705 - 1950 WP_141414791.1 glycoside hydrolase family 127 protein -
GTQ93_RS21755 4577716..4579116 - 1401 WP_023304613.1 MFS transporter -
GTQ93_RS21760 4579342..4580160 + 819 WP_032649828.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T146727 WP_071788668.1 NZ_CP047570:4575096-4575281 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T146727 NZ_CP062778:1080207-1080542 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT146727 WP_023295606.1 NZ_CP047570:4575296-4575700 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT146727 NZ_CP062778:1079959-1080207 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References