Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 621674..622331 Replicon chromosome
Accession NZ_CP047570
Organism Enterobacter hormaechei strain F2

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag GTQ93_RS03060 Protein ID WP_017382887.1
Coordinates 621921..622331 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GTQ93_RS03055 Protein ID WP_003863437.1
Coordinates 621674..621940 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTQ93_RS03035 617080..618513 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
GTQ93_RS03040 618630..619361 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
GTQ93_RS03045 619628..620287 + 660 WP_003863433.1 hemolysin III family protein -
GTQ93_RS03050 620399..621379 - 981 WP_128771922.1 tRNA-modifying protein YgfZ -
GTQ93_RS03055 621674..621940 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GTQ93_RS03060 621921..622331 + 411 WP_017382887.1 protein YgfX Toxin
GTQ93_RS03065 622333..622854 - 522 WP_015571793.1 flavodoxin FldB -
GTQ93_RS03070 622956..623852 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GTQ93_RS03075 623881..624594 + 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GTQ93_RS03080 624600..626333 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T146712 WP_017382887.1 NZ_CP047570:621921-622331 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T146712 NZ_CP062774:c5042301-5042128 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT146712 WP_003863437.1 NZ_CP047570:621674-621940 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT146712 NZ_CP062774:c5042625-5042329 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References