Detailed information of TA system TA146702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 3679940..3680462
• Replicon: chromosome
• Accession: NZ_CP047555
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: DXN18_RS17930
• Protein ID: WP_000221343.1
• Coordinates: 3679940..3680224 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: DXN18_RS17935
• Protein ID: WP_000885424.1
• Coordinates: 3680214..3680462 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN18_RS17910 (3676015)	3676015..3677523	-	1509	WP_000199411.1	FAD-dependent oxidoreductase	-
DXN18_RS17915 (3677568)	3677568..3678056	+	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
DXN18_RS17920 (3678249)	3678249..3679328	+	1080	WP_000954688.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
DXN18_RS17925 (3679380)	3679380..3679769	-	390	WP_000194089.1	RidA family protein	-
DXN18_RS17930 (3679940)	3679940..3680224	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DXN18_RS17935 (3680214)	3680214..3680462	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DXN18_RS17940 (3680614)	3680614..3680829	+	216	WP_000206207.1	hypothetical protein	-
DXN18_RS17945 (3680819)	3680819..3681151	+	333	WP_000253154.1	DUF1493 family protein	-
DXN18_RS17950 (3681294)	3681294..3682202	+	909	WP_010989018.1	hypothetical protein	-
DXN18_RS17955 (3682258)	3682258..3682972	-	715	Protein_3498	helix-turn-helix domain-containing protein	-
DXN18_RS17960 (3683780)	3683780..3685246	-	1467	WP_000987828.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T146702 WP_000221343.1 NZ_CP047555:c3680224-3679940 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T146702 NZ_CP062774:c3369980-3369606 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT146702 WP_000885424.1 NZ_CP047555:c3680462-3680214 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT146702 NZ_CP062774:c3370401-3370027 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5