Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2631760..2632380 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN18_RS12660 Protein ID WP_001280991.1
Coordinates 2631760..2631978 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN18_RS12665 Protein ID WP_000344807.1
Coordinates 2632006..2632380 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS12620 (2626984) 2626984..2627553 + 570 WP_000779803.1 YbaY family lipoprotein -
DXN18_RS12625 (2627586) 2627586..2627975 - 390 WP_000961285.1 MGMT family protein -
DXN18_RS12635 (2628206) 2628206..2629756 - 1551 WP_000213139.1 EAL domain-containing protein -
DXN18_RS12640 (2629981) 2629981..2630241 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN18_RS12645 (2630247) 2630247..2630387 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN18_RS12650 (2630443) 2630443..2630913 - 471 WP_000136181.1 YlaC family protein -
DXN18_RS12655 (2631030) 2631030..2631581 - 552 WP_001278792.1 maltose O-acetyltransferase -
DXN18_RS12660 (2631760) 2631760..2631978 - 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN18_RS12665 (2632006) 2632006..2632380 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN18_RS12670 (2632876) 2632876..2636025 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN18_RS12675 (2636048) 2636048..2637241 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146701 WP_001280991.1 NZ_CP047555:c2631978-2631760 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146701 NZ_CP062774:c3006220-3006117 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146701 WP_000344807.1 NZ_CP047555:c2632380-2632006 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146701 NZ_CP062774:3006079-3006350 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References