Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1989283..1989859 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag DXN18_RS09560 Protein ID WP_001131963.1
Coordinates 1989283..1989570 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag DXN18_RS09565 Protein ID WP_000063142.1
Coordinates 1989557..1989859 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS09550 (1984393) 1984393..1987902 - 3510 WP_001043484.1 type I restriction-modification system endonuclease -
DXN18_RS09555 (1988100) 1988100..1989014 + 915 WP_000290512.1 restriction endonuclease -
DXN18_RS09560 (1989283) 1989283..1989570 + 288 WP_001131963.1 BrnT family toxin Toxin
DXN18_RS09565 (1989557) 1989557..1989859 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
DXN18_RS09570 (1989934) 1989934..1990890 - 957 WP_000187839.1 GTPase -
DXN18_RS09575 (1990901) 1990901..1991104 - 204 WP_000460616.1 YbdD/YjiX family protein -
DXN18_RS09580 (1991199) 1991199..1993349 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T146697 WP_001131963.1 NZ_CP047555:1989283-1989570 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T146697 NZ_CP062774:c2211418-2211311 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT146697 WP_000063142.1 NZ_CP047555:1989557-1989859 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT146697 NZ_CP062774:2211466-2211525 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References