146696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1895082..1895598 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DXN18_RS09165 Protein ID WP_000220578.1
Coordinates 1895314..1895598 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DXN18_RS09160 Protein ID WP_000212724.1
Coordinates 1895082..1895324 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS09140 (1890102) 1890102..1891235 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
DXN18_RS09145 (1891219) 1891219..1892337 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DXN18_RS09150 (1892334) 1892334..1893074 + 741 WP_000779263.1 KDGP aldolase family protein -
DXN18_RS09155 (1893091) 1893091..1895004 + 1914 WP_001212137.1 BglG family transcription antiterminator -
DXN18_RS09160 (1895082) 1895082..1895324 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DXN18_RS09165 (1895314) 1895314..1895598 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN18_RS09170 (1895602) 1895602..1896066 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DXN18_RS09175 (1896187) 1896187..1898325 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DXN18_RS09180 (1898734) 1898734..1900386 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T146696 WP_000220578.1 NZ_CP047555:1895314-1895598 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146696 NZ_CP062774:c2210882-2210775 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146696 WP_000212724.1 NZ_CP047555:1895082-1895324 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146696 NZ_CP062774:2210935-2210996 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References