Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1684739..1685520 | Replicon | chromosome |
| Accession | NZ_CP047555 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | DXN18_RS08060 | Protein ID | WP_000626099.1 |
| Coordinates | 1685029..1685520 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | DXN18_RS08055 | Protein ID | WP_001110452.1 |
| Coordinates | 1684739..1685032 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN18_RS08025 (1681063) | 1681063..1681968 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| DXN18_RS08030 (1682262) | 1682262..1682531 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| DXN18_RS08035 (1682539) | 1682539..1682754 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| DXN18_RS08040 (1682777) | 1682777..1683064 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| DXN18_RS08045 (1683061) | 1683061..1683936 | - | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| DXN18_RS08050 (1684201) | 1684201..1684422 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| DXN18_RS08055 (1684739) | 1684739..1685032 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| DXN18_RS08060 (1685029) | 1685029..1685520 | + | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| DXN18_RS08065 (1685768) | 1685768..1686520 | - | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| DXN18_RS08070 (1686623) | 1686623..1686697 | - | 75 | Protein_1565 | porin family protein | - |
| DXN18_RS08075 (1687730) | 1687730..1688107 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| DXN18_RS08080 (1688179) | 1688179..1688511 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| DXN18_RS08085 (1688602) | 1688602..1688679 | + | 78 | Protein_1568 | helix-turn-helix domain-containing protein | - |
| DXN18_RS08090 (1688870) | 1688870..1689742 | + | 873 | WP_033567082.1 | ParA family protein | - |
| DXN18_RS08095 (1689739) | 1689739..1690095 | + | 357 | WP_033567083.1 | hypothetical protein | - |
| DXN18_RS08100 (1690092) | 1690092..1690334 | + | 243 | WP_197603740.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T146695 WP_000626099.1 NZ_CP047555:1685029-1685520 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T146695 NZ_CP062774:1093268-1093603 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT146695 WP_001110452.1 NZ_CP047555:1684739-1685032 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT146695 NZ_CP062774:1093020-1093268 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|