Detailed information of TA system TA146689

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 297152..297812
• Replicon: chromosome
• Accession: NZ_CP047555
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: DXN18_RS01445
• Protein ID: WP_000244756.1
• Coordinates: 297152..297565 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: DXN18_RS01450
• Protein ID: WP_000351186.1
• Coordinates: 297546..297812 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN18_RS01425 (293093)	293093..294826	-	1734	WP_000813394.1	single-stranded-DNA-specific exonuclease RecJ	-
DXN18_RS01430 (294832)	294832..295545	-	714	WP_000745625.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DXN18_RS01435 (295569)	295569..296465	-	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
DXN18_RS01440 (296578)	296578..297099	+	522	WP_001055885.1	flavodoxin FldB	-
DXN18_RS01445 (297152)	297152..297565	-	414	WP_000244756.1	protein YgfX	Toxin
DXN18_RS01450 (297546)	297546..297812	-	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
DXN18_RS01455 (298062)	298062..299042	+	981	WP_000874172.1	tRNA-modifying protein YgfZ	-
DXN18_RS01460 (299158)	299158..299817	-	660	WP_000250289.1	hemolysin III family protein	-
DXN18_RS01465 (299981)	299981..300292	-	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
DXN18_RS01470 (300451)	300451..301884	+	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T146689 WP_000244756.1 NZ_CP047555:c297565-297152 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T146689 NZ_CP062774:408069-408596 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT146689 WP_000351186.1 NZ_CP047555:c297812-297546 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT146689 NZ_CP062774:407796-408062 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4