Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4789471..4790231 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN27_RS23515 Protein ID WP_000533909.1
Coordinates 4789471..4789956 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN27_RS23520 Protein ID WP_000965886.1
Coordinates 4789944..4790231 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS23485 (4784541) 4784541..4785203 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN27_RS23490 (4785422) 4785422..4786396 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN27_RS23495 (4786446) 4786446..4787156 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN27_RS23500 (4787595) 4787595..4787885 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN27_RS23505 (4788174) 4788174..4788386 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN27_RS23510 (4788560) 4788560..4789099 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN27_RS23515 (4789471) 4789471..4789956 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN27_RS23520 (4789944) 4789944..4790231 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN27_RS23525 (4790409) 4790409..4790876 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN27_RS23530 (4791048) 4791048..4791323 - 276 Protein_4588 IS3 family transposase -
DXN27_RS23535 (4791505) 4791505..4793574 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN27_RS23540 (4793584) 4793584..4794495 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN27_RS23545 (4794634) 4794634..4794936 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146685 WP_000533909.1 NZ_CP047553:c4789956-4789471 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146685 NZ_CP062772:71590-71748 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146685 WP_000965886.1 NZ_CP047553:c4790231-4789944 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146685 NZ_CP062772:71327-71525 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References