Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4125018..4125678 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN27_RS20245 Protein ID WP_000244756.1
Coordinates 4125018..4125431 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN27_RS20250 Protein ID WP_000351186.1
Coordinates 4125412..4125678 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS20225 (4120959) 4120959..4122692 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
DXN27_RS20230 (4122698) 4122698..4123411 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN27_RS20235 (4123435) 4123435..4124331 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN27_RS20240 (4124444) 4124444..4124965 + 522 WP_001055885.1 flavodoxin FldB -
DXN27_RS20245 (4125018) 4125018..4125431 - 414 WP_000244756.1 protein YgfX Toxin
DXN27_RS20250 (4125412) 4125412..4125678 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN27_RS20255 (4125928) 4125928..4126908 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN27_RS20260 (4127024) 4127024..4127683 - 660 WP_000250289.1 hemolysin III family protein -
DXN27_RS20265 (4127847) 4127847..4128158 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN27_RS20270 (4128317) 4128317..4129750 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146682 WP_000244756.1 NZ_CP047553:c4125431-4125018 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146682 NZ_CP062771:c5093266-5093093 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146682 WP_000351186.1 NZ_CP047553:c4125678-4125412 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146682 NZ_CP062771:c5093590-5093294 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References