Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4114166..4114791 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN27_RS20180 Protein ID WP_000911336.1
Coordinates 4114166..4114564 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN27_RS20185 Protein ID WP_000557549.1
Coordinates 4114564..4114791 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS20165 (4110842) 4110842..4111426 - 585 WP_001244638.1 fimbrial protein -
DXN27_RS20170 (4112145) 4112145..4112777 - 633 WP_000835265.1 YfdX family protein -
DXN27_RS20175 (4112824) 4112824..4113360 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN27_RS20180 (4114166) 4114166..4114564 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN27_RS20185 (4114564) 4114564..4114791 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN27_RS20190 (4114968) 4114968..4115219 + 252 WP_001540858.1 hypothetical protein -
DXN27_RS20195 (4115494) 4115494..4116300 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN27_RS20205 (4116585) 4116585..4117343 - 759 WP_000244329.1 amidase activator ActS -
DXN27_RS20210 (4117608) 4117608..4118153 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN27_RS20215 (4118229) 4118229..4119746 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146681 WP_000911336.1 NZ_CP047553:c4114564-4114166 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146681 NZ_CP062771:c4996452-4996102 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146681 WP_000557549.1 NZ_CP047553:c4114791-4114564 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146681 NZ_CP062771:c4996697-4996446 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References