146671

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2510501..2511023 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN27_RS12265 Protein ID WP_000221343.1
Coordinates 2510501..2510785 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN27_RS12270 Protein ID WP_000885424.1
Coordinates 2510775..2511023 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS12245 (2506576) 2506576..2508084 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
DXN27_RS12250 (2508129) 2508129..2508617 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN27_RS12255 (2508810) 2508810..2509889 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN27_RS12260 (2509941) 2509941..2510330 - 390 WP_000194089.1 RidA family protein -
DXN27_RS12265 (2510501) 2510501..2510785 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN27_RS12270 (2510775) 2510775..2511023 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN27_RS12275 (2511175) 2511175..2511390 + 216 WP_000206207.1 hypothetical protein -
DXN27_RS12280 (2511380) 2511380..2511712 + 333 WP_000253154.1 DUF1493 family protein -
DXN27_RS12285 (2511855) 2511855..2512763 + 909 WP_010989018.1 hypothetical protein -
DXN27_RS12290 (2512819) 2512819..2513533 - 715 Protein_2384 helix-turn-helix domain-containing protein -
DXN27_RS12295 (2514341) 2514341..2515807 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146671 WP_000221343.1 NZ_CP047553:c2510785-2510501 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146671 NZ_CP062771:3149079-3149186 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146671 WP_000885424.1 NZ_CP047553:c2511023-2510775 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146671 NZ_CP062771:c3149026-3148965 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References