Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1462321..1462941 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN27_RS06995 Protein ID WP_001280991.1
Coordinates 1462321..1462539 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN27_RS07000 Protein ID WP_000344807.1
Coordinates 1462567..1462941 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS06955 (1457869) 1457869..1458114 + 246 Protein_1344 YbaY family lipoprotein -
DXN27_RS06960 (1458147) 1458147..1458536 - 390 WP_000961285.1 MGMT family protein -
DXN27_RS06970 (1458767) 1458767..1460317 - 1551 WP_000213139.1 EAL domain-containing protein -
DXN27_RS06975 (1460542) 1460542..1460802 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN27_RS06980 (1460808) 1460808..1460948 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN27_RS06985 (1461004) 1461004..1461474 - 471 WP_000136181.1 YlaC family protein -
DXN27_RS06990 (1461591) 1461591..1462142 - 552 WP_001278792.1 maltose O-acetyltransferase -
DXN27_RS06995 (1462321) 1462321..1462539 - 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN27_RS07000 (1462567) 1462567..1462941 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN27_RS07005 (1463437) 1463437..1466586 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN27_RS07010 (1466609) 1466609..1467802 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146670 WP_001280991.1 NZ_CP047553:c1462539-1462321 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146670 NZ_CP062771:3148543-3148650 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146670 WP_000344807.1 NZ_CP047553:c1462941-1462567 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146670 NZ_CP062771:c3148495-3148436 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References