Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 727005..727521 Replicon chromosome
Accession NZ_CP047553
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10231

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DXN27_RS03505 Protein ID WP_000220578.1
Coordinates 727237..727521 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DXN27_RS03500 Protein ID WP_000212724.1
Coordinates 727005..727247 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN27_RS03480 (722025) 722025..723158 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
DXN27_RS03485 (723142) 723142..724260 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DXN27_RS03490 (724257) 724257..724997 + 741 WP_000779263.1 KDGP aldolase family protein -
DXN27_RS03495 (725014) 725014..726927 + 1914 WP_001212137.1 BglG family transcription antiterminator -
DXN27_RS03500 (727005) 727005..727247 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DXN27_RS03505 (727237) 727237..727521 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN27_RS03510 (727525) 727525..727989 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DXN27_RS03515 (728110) 728110..730248 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DXN27_RS03520 (730657) 730657..732309 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T146665 WP_000220578.1 NZ_CP047553:727237-727521 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146665 NZ_CP062771:1093245-1093580 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146665 WP_000212724.1 NZ_CP047553:727005-727247 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146665 NZ_CP062771:1092997-1093245 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References