146661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 167210..168833 Replicon plasmid unnamedA
Accession NZ_CP047551
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN07_RS25400 Protein ID WP_000088046.1
Coordinates 167210..168535 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN07_RS25405 Protein ID WP_024136327.1
Coordinates 168540..168833 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS25370 (DXN07_025290) 163880..164179 - 300 WP_001572440.1 hypothetical protein -
DXN07_RS25375 (DXN07_025295) 164234..164470 - 237 Protein_183 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN07_RS25380 (DXN07_025300) 164924..165349 - 426 WP_001043843.1 hypothetical protein -
DXN07_RS25385 (DXN07_025305) 165603..166418 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN07_RS25390 (DXN07_025310) 166431..166841 - 411 WP_000985911.1 hypothetical protein -
DXN07_RS25395 (DXN07_025315) 166943..167149 - 207 WP_000134171.1 hypothetical protein -
DXN07_RS25400 (DXN07_025320) 167210..168535 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN07_RS25405 (DXN07_025325) 168540..168833 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN07_RS25410 (DXN07_025330) 169437..169829 - 393 WP_000341066.1 hypothetical protein -
DXN07_RS25415 (DXN07_025335) 170202..170543 + 342 WP_001151575.1 hypothetical protein -
DXN07_RS25420 (DXN07_025340) 170635..170826 + 192 WP_000398480.1 hypothetical protein -
DXN07_RS25425 (DXN07_025345) 170876..171157 + 282 WP_000077926.1 hypothetical protein -
DXN07_RS25825 171498..171629 - 132 WP_000374059.1 hypothetical protein -
DXN07_RS25430 (DXN07_025350) 171720..172961 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / dfrA12 - 1..240317 240317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146661 WP_000088046.1 NZ_CP047551:c168535-167210 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146661 NZ_CP062771:c457211-456726 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146661 WP_024136327.1 NZ_CP047551:c168833-168540 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146661 NZ_CP062771:c457480-457202 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References