Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4479683..4480464 | Replicon | chromosome |
| Accession | NZ_CP047550 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | DXN07_RS22060 | Protein ID | WP_000626099.1 |
| Coordinates | 4479683..4480174 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | DXN07_RS22065 | Protein ID | WP_001110452.1 |
| Coordinates | 4480171..4480464 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN07_RS22020 (4474869) | 4474869..4475111 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| DXN07_RS22025 (4475108) | 4475108..4475464 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| DXN07_RS22030 (4475461) | 4475461..4476333 | - | 873 | WP_033567082.1 | ParA family protein | - |
| DXN07_RS22035 (4476524) | 4476524..4476601 | - | 78 | Protein_4318 | helix-turn-helix domain-containing protein | - |
| DXN07_RS22040 (4476692) | 4476692..4477024 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| DXN07_RS22045 (4477096) | 4477096..4477473 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| DXN07_RS22050 (4478506) | 4478506..4478580 | + | 75 | Protein_4321 | porin family protein | - |
| DXN07_RS22055 (4478683) | 4478683..4479435 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| DXN07_RS22060 (4479683) | 4479683..4480174 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| DXN07_RS22065 (4480171) | 4480171..4480464 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| DXN07_RS22070 (4480781) | 4480781..4481002 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| DXN07_RS22075 (4481267) | 4481267..4482142 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| DXN07_RS22080 (4482139) | 4482139..4482426 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| DXN07_RS22085 (4482449) | 4482449..4482664 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| DXN07_RS22090 (4482672) | 4482672..4482941 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| DXN07_RS22095 (4483235) | 4483235..4484140 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T146658 WP_000626099.1 NZ_CP047550:c4480174-4479683 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T146658 NZ_CP062771:365365-365640 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT146658 WP_001110452.1 NZ_CP047550:c4480464-4480171 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT146658 NZ_CP062771:365637-365996 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |