146658

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4479683..4480464 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN07_RS22060 Protein ID WP_000626099.1
Coordinates 4479683..4480174 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN07_RS22065 Protein ID WP_001110452.1
Coordinates 4480171..4480464 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS22020 (4474869) 4474869..4475111 - 243 WP_197603740.1 hypothetical protein -
DXN07_RS22025 (4475108) 4475108..4475464 - 357 WP_033567083.1 hypothetical protein -
DXN07_RS22030 (4475461) 4475461..4476333 - 873 WP_033567082.1 ParA family protein -
DXN07_RS22035 (4476524) 4476524..4476601 - 78 Protein_4318 helix-turn-helix domain-containing protein -
DXN07_RS22040 (4476692) 4476692..4477024 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN07_RS22045 (4477096) 4477096..4477473 + 378 WP_000916345.1 EthD family reductase -
DXN07_RS22050 (4478506) 4478506..4478580 + 75 Protein_4321 porin family protein -
DXN07_RS22055 (4478683) 4478683..4479435 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN07_RS22060 (4479683) 4479683..4480174 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN07_RS22065 (4480171) 4480171..4480464 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN07_RS22070 (4480781) 4480781..4481002 + 222 WP_001576552.1 hypothetical protein -
DXN07_RS22075 (4481267) 4481267..4482142 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN07_RS22080 (4482139) 4482139..4482426 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN07_RS22085 (4482449) 4482449..4482664 + 216 WP_001595136.1 hypothetical protein -
DXN07_RS22090 (4482672) 4482672..4482941 + 270 WP_010989096.1 hypothetical protein -
DXN07_RS22095 (4483235) 4483235..4484140 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(85-145)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146658 WP_000626099.1 NZ_CP047550:c4480174-4479683 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146658 NZ_CP062771:365365-365640 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146658 WP_001110452.1 NZ_CP047550:c4480464-4480171 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146658 NZ_CP062771:365637-365996 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AK7


Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References