146651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2484921..2485443 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN07_RS12195 Protein ID WP_000221343.1
Coordinates 2485159..2485443 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN07_RS12190 Protein ID WP_000885424.1
Coordinates 2484921..2485169 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS12165 (2480137) 2480137..2481603 + 1467 WP_000987828.1 hypothetical protein -
DXN07_RS12170 (2482411) 2482411..2483125 + 715 Protein_2388 helix-turn-helix domain-containing protein -
DXN07_RS12175 (2483181) 2483181..2484089 - 909 WP_010989018.1 hypothetical protein -
DXN07_RS12180 (2484232) 2484232..2484564 - 333 WP_000253154.1 DUF1493 family protein -
DXN07_RS12185 (2484554) 2484554..2484769 - 216 WP_000206207.1 hypothetical protein -
DXN07_RS12190 (2484921) 2484921..2485169 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN07_RS12195 (2485159) 2485159..2485443 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN07_RS12200 (2485614) 2485614..2486003 + 390 WP_000194089.1 RidA family protein -
DXN07_RS12205 (2486055) 2486055..2487134 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN07_RS12210 (2487327) 2487327..2487815 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN07_RS12215 (2487860) 2487860..2489368 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146651 WP_000221343.1 NZ_CP047550:2485159-2485443 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146651 NZ_CP062769:4767806-4768147 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146651 WP_000885424.1 NZ_CP047550:2484921-2485169 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146651 NZ_CP062769:c4767811-4767735 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References