146641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881158..881783 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN07_RS04285 Protein ID WP_000911336.1
Coordinates 881385..881783 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN07_RS04280 Protein ID WP_000557549.1
Coordinates 881158..881385 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS04250 (876203) 876203..877720 + 1518 WP_000003339.1 lysine--tRNA ligase -
DXN07_RS04255 (877796) 877796..878341 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN07_RS04260 (878606) 878606..879364 + 759 WP_000244329.1 amidase activator ActS -
DXN07_RS04270 (879649) 879649..880455 - 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN07_RS04275 (880730) 880730..880981 - 252 WP_001540858.1 hypothetical protein -
DXN07_RS04280 (881158) 881158..881385 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN07_RS04285 (881385) 881385..881783 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN07_RS04290 (882589) 882589..883125 + 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN07_RS04295 (883172) 883172..883804 + 633 WP_000835265.1 YfdX family protein -
DXN07_RS04300 (884523) 884523..885107 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146641 WP_000911336.1 NZ_CP047550:881385-881783 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146641 NZ_CP062769:3006422-3006700 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146641 WP_000557549.1 NZ_CP047550:881158-881385 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146641 NZ_CP062769:3006229-3006420 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References