Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870271..870931 Replicon chromosome
Accession NZ_CP047550
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10057

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN07_RS04220 Protein ID WP_000244756.1
Coordinates 870518..870931 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN07_RS04215 Protein ID WP_000351186.1
Coordinates 870271..870537 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN07_RS04195 (866199) 866199..867632 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
DXN07_RS04200 (867791) 867791..868102 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN07_RS04205 (868266) 868266..868925 + 660 WP_000250289.1 hemolysin III family protein -
DXN07_RS04210 (869041) 869041..870021 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN07_RS04215 (870271) 870271..870537 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN07_RS04220 (870518) 870518..870931 + 414 WP_000244756.1 protein YgfX Toxin
DXN07_RS04225 (870984) 870984..871505 - 522 WP_001055885.1 flavodoxin FldB -
DXN07_RS04230 (871618) 871618..872514 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN07_RS04235 (872538) 872538..873251 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN07_RS04240 (873257) 873257..874990 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146640 WP_000244756.1 NZ_CP047550:870518-870931 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146640 NZ_CP062769:c2757460-2757284 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146640 WP_000351186.1 NZ_CP047550:870271-870537 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146640 NZ_CP062769:c2757238-2756822 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References