Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 53094..54717 Replicon plasmid unnamed
Accession NZ_CP047549
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN26_RS24705 Protein ID WP_000088046.1
Coordinates 53392..54717 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN26_RS24700 Protein ID WP_024136327.1
Coordinates 53094..53387 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS24675 (DXN26_024605) 48966..50207 + 1242 WP_001053338.1 VWA domain-containing protein -
DXN26_RS25810 50298..50429 + 132 WP_000374059.1 hypothetical protein -
DXN26_RS24680 (DXN26_024610) 50770..51051 - 282 WP_000077926.1 hypothetical protein -
DXN26_RS24685 (DXN26_024615) 51101..51292 - 192 WP_000398480.1 hypothetical protein -
DXN26_RS24690 (DXN26_024620) 51384..51725 - 342 WP_001151575.1 hypothetical protein -
DXN26_RS24695 (DXN26_024625) 52098..52490 + 393 WP_000341066.1 hypothetical protein -
DXN26_RS24700 (DXN26_024630) 53094..53387 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN26_RS24705 (DXN26_024635) 53392..54717 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN26_RS24710 (DXN26_024640) 54778..54984 + 207 WP_000134171.1 hypothetical protein -
DXN26_RS24715 (DXN26_024645) 55086..55496 + 411 WP_000985911.1 hypothetical protein -
DXN26_RS24720 (DXN26_024650) 55509..56324 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN26_RS24725 (DXN26_024655) 56578..57003 + 426 WP_001043843.1 hypothetical protein -
DXN26_RS24730 (DXN26_024660) 57457..57693 + 237 Protein_62 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN26_RS24735 (DXN26_024665) 57748..58047 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / dfrA12 / oqxA / oqxB - 1..249152 249152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146636 WP_000088046.1 NZ_CP047549:53392-54717 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146636 NZ_CP062769:751358-751672 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146636 WP_024136327.1 NZ_CP047549:53094-53387 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146636 NZ_CP062769:751669-752085 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References