Detailed information of TA system TA146620

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1463680..1464300
• Replicon: chromosome
• Accession: NZ_CP047548
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: DXN26_RS07000
• Protein ID: WP_001280991.1
• Coordinates: 1463680..1463898 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: DXN26_RS07005
• Protein ID: WP_000344807.1
• Coordinates: 1463926..1464300 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN26_RS06960 (1458904)	1458904..1459473	+	570	WP_000779803.1	YbaY family lipoprotein	-
DXN26_RS06965 (1459506)	1459506..1459895	-	390	WP_000961285.1	MGMT family protein	-
DXN26_RS06975 (1460126)	1460126..1461676	-	1551	WP_000213139.1	EAL domain-containing protein	-
DXN26_RS06980 (1461901)	1461901..1462161	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
DXN26_RS06985 (1462167)	1462167..1462307	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
DXN26_RS06990 (1462363)	1462363..1462833	-	471	WP_000136181.1	YlaC family protein	-
DXN26_RS06995 (1462950)	1462950..1463501	-	552	WP_001278792.1	maltose O-acetyltransferase	-
DXN26_RS07000 (1463680)	1463680..1463898	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
DXN26_RS07005 (1463926)	1463926..1464300	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
DXN26_RS07010 (1464796)	1464796..1467945	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
DXN26_RS07015 (1467968)	1467968..1469161	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T146620 WP_001280991.1 NZ_CP047548:c1463898-1463680 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T146620 NZ_CP062766:c4515764-4515366 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT146620 WP_000344807.1 NZ_CP047548:c1464300-1463926 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT146620 NZ_CP062766:c4516060-4515767 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0