Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 516658..517439 Replicon chromosome
Accession NZ_CP047548
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN26_RS02400 Protein ID WP_000626099.1
Coordinates 516948..517439 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN26_RS02395 Protein ID WP_001110452.1
Coordinates 516658..516951 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS02365 (512982) 512982..513887 + 906 WP_001268200.1 YjiK family protein -
DXN26_RS02370 (514181) 514181..514450 - 270 WP_010989096.1 hypothetical protein -
DXN26_RS02375 (514458) 514458..514673 - 216 WP_001595136.1 hypothetical protein -
DXN26_RS02380 (514696) 514696..514983 - 288 WP_001269916.1 transcriptional regulator RtsB -
DXN26_RS02385 (514980) 514980..515855 - 876 WP_000921674.1 AraC family transcriptional regulator -
DXN26_RS02390 (516120) 516120..516341 - 222 WP_001576552.1 hypothetical protein -
DXN26_RS02395 (516658) 516658..516951 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN26_RS02400 (516948) 516948..517439 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN26_RS02405 (517687) 517687..518439 - 753 WP_000842434.1 non-specific acid phosphatase -
DXN26_RS02410 (518542) 518542..518616 - 75 Protein_452 porin family protein -
DXN26_RS02415 (519649) 519649..520026 - 378 WP_000916345.1 EthD family reductase -
DXN26_RS02420 (520098) 520098..520430 + 333 WP_001165471.1 MerR family transcriptional regulator -
DXN26_RS02425 (520521) 520521..520598 + 78 Protein_455 helix-turn-helix domain-containing protein -
DXN26_RS02430 (520789) 520789..521661 + 873 WP_033567082.1 ParA family protein -
DXN26_RS02435 (521658) 521658..522014 + 357 WP_033567083.1 hypothetical protein -
DXN26_RS02440 (522011) 522011..522253 + 243 WP_197603740.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146614 WP_000626099.1 NZ_CP047548:516948-517439 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146614 NZ_CP062766:3155184-3155291 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146614 WP_001110452.1 NZ_CP047548:516658-516951 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146614 NZ_CP062766:c3155131-3155070 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References