Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4477251..4478032 | Replicon | chromosome |
| Accession | NZ_CP047546 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | DXN28_RS22060 | Protein ID | WP_000626099.1 |
| Coordinates | 4477251..4477742 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | DXN28_RS22065 | Protein ID | WP_001110452.1 |
| Coordinates | 4477739..4478032 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN28_RS22020 (4472437) | 4472437..4472679 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| DXN28_RS22025 (4472676) | 4472676..4473032 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| DXN28_RS22030 (4473029) | 4473029..4473901 | - | 873 | WP_033567082.1 | ParA family protein | - |
| DXN28_RS22035 (4474092) | 4474092..4474169 | - | 78 | Protein_4317 | helix-turn-helix domain-containing protein | - |
| DXN28_RS22040 (4474260) | 4474260..4474592 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| DXN28_RS22045 (4474664) | 4474664..4475041 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| DXN28_RS22050 (4476074) | 4476074..4476148 | + | 75 | Protein_4320 | porin family protein | - |
| DXN28_RS22055 (4476251) | 4476251..4477003 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| DXN28_RS22060 (4477251) | 4477251..4477742 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| DXN28_RS22065 (4477739) | 4477739..4478032 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| DXN28_RS22070 (4478349) | 4478349..4478570 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| DXN28_RS22075 (4478835) | 4478835..4479710 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| DXN28_RS22080 (4479707) | 4479707..4479994 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| DXN28_RS22085 (4480017) | 4480017..4480232 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| DXN28_RS22090 (4480240) | 4480240..4480509 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| DXN28_RS22095 (4480803) | 4480803..4481708 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T146608 WP_000626099.1 NZ_CP047546:c4477742-4477251 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T146608 NZ_CP062766:1093268-1093603 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT146608 WP_001110452.1 NZ_CP047546:c4478032-4477739 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT146608 NZ_CP062766:1093020-1093268 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |