Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4267173..4267689 Replicon chromosome
Accession NZ_CP047546
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DXN28_RS20955 Protein ID WP_000220578.1
Coordinates 4267173..4267457 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DXN28_RS20960 Protein ID WP_000212724.1
Coordinates 4267447..4267689 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN28_RS20940 (4262385) 4262385..4264037 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
DXN28_RS20945 (4264446) 4264446..4266584 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DXN28_RS20950 (4266705) 4266705..4267169 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DXN28_RS20955 (4267173) 4267173..4267457 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN28_RS20960 (4267447) 4267447..4267689 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DXN28_RS20965 (4267767) 4267767..4269680 - 1914 WP_001212137.1 BglG family transcription antiterminator -
DXN28_RS20970 (4269697) 4269697..4270437 - 741 WP_000779263.1 KDGP aldolase family protein -
DXN28_RS20975 (4270434) 4270434..4271552 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DXN28_RS20980 (4271536) 4271536..4272669 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T146607 WP_000220578.1 NZ_CP047546:c4267457-4267173 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146607 NZ_CP062766:946473-946880 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146607 WP_000212724.1 NZ_CP047546:c4267689-4267447 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146607 NZ_CP062766:946226-946492 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References