Detailed information of TA system TA146602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3527713..3528333
• Replicon: chromosome
• Accession: NZ_CP047546
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: DXN28_RS17450
• Protein ID: WP_001280991.1
• Coordinates: 3528115..3528333 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: DXN28_RS17445
• Protein ID: WP_000344807.1
• Coordinates: 3527713..3528087 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN28_RS17435 (3522852)	3522852..3524045	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DXN28_RS17440 (3524068)	3524068..3527217	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
DXN28_RS17445 (3527713)	3527713..3528087	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
DXN28_RS17450 (3528115)	3528115..3528333	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
DXN28_RS17455 (3528512)	3528512..3529063	+	552	WP_001278792.1	maltose O-acetyltransferase	-
DXN28_RS17460 (3529180)	3529180..3529650	+	471	WP_000136181.1	YlaC family protein	-
DXN28_RS17465 (3529706)	3529706..3529846	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
DXN28_RS17470 (3529852)	3529852..3530112	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
DXN28_RS17475 (3530337)	3530337..3531887	+	1551	WP_000213139.1	EAL domain-containing protein	-
DXN28_RS17485 (3532118)	3532118..3532507	+	390	WP_000961285.1	MGMT family protein	-
DXN28_RS17490 (3532540)	3532540..3533109	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T146602 WP_001280991.1 NZ_CP047546:3528115-3528333 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T146602 NZ_CP062766:408070-408597 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT146602 WP_000344807.1 NZ_CP047546:3527713-3528087 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT146602 NZ_CP062766:407797-408063 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0