Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206642..207402 Replicon chromosome
Accession NZ_CP047546
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10236

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN28_RS00965 Protein ID WP_000533909.1
Coordinates 206917..207402 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN28_RS00960 Protein ID WP_000965886.1
Coordinates 206642..206929 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN28_RS00935 (201937) 201937..202239 + 303 WP_000605590.1 YsaB family lipoprotein -
DXN28_RS00940 (202378) 202378..203289 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN28_RS00945 (203299) 203299..205368 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN28_RS00950 (205550) 205550..205825 + 276 Protein_189 IS3 family transposase -
DXN28_RS00955 (205997) 205997..206464 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN28_RS00960 (206642) 206642..206929 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN28_RS00965 (206917) 206917..207402 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN28_RS00970 (207774) 207774..208313 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN28_RS00975 (208487) 208487..208699 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN28_RS00980 (208988) 208988..209278 - 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN28_RS00985 (209717) 209717..210427 + 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN28_RS00990 (210477) 210477..211451 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN28_RS00995 (211670) 211670..212332 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146587 WP_000533909.1 NZ_CP047546:206917-207402 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146587 NZ_CP062763:3604519-3604806 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146587 WP_000965886.1 NZ_CP047546:206642-206929 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146587 NZ_CP062763:3604328-3604519 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References