Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 134794..136417 Replicon plasmid unnamed
Accession NZ_CP047545
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN29_RS25335 Protein ID WP_000088046.1
Coordinates 135092..136417 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN29_RS25330 Protein ID WP_024136327.1
Coordinates 134794..135087 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN29_RS25305 (DXN29_025210) 130666..131907 + 1242 WP_001053338.1 VWA domain-containing protein -
DXN29_RS25965 131998..132129 + 132 WP_000374059.1 hypothetical protein -
DXN29_RS25310 (DXN29_025215) 132470..132751 - 282 WP_000077926.1 hypothetical protein -
DXN29_RS25315 (DXN29_025220) 132801..132992 - 192 WP_000398480.1 hypothetical protein -
DXN29_RS25320 (DXN29_025225) 133084..133425 - 342 WP_001151575.1 hypothetical protein -
DXN29_RS25325 (DXN29_025230) 133798..134190 + 393 WP_000341066.1 hypothetical protein -
DXN29_RS25330 (DXN29_025235) 134794..135087 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN29_RS25335 (DXN29_025240) 135092..136417 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN29_RS25340 (DXN29_025245) 136478..136684 + 207 WP_000134171.1 hypothetical protein -
DXN29_RS25345 (DXN29_025250) 136786..137196 + 411 WP_000985911.1 hypothetical protein -
DXN29_RS25350 (DXN29_025255) 137209..138024 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN29_RS25355 (DXN29_025260) 138278..138703 + 426 WP_001043843.1 hypothetical protein -
DXN29_RS25360 (DXN29_025265) 139157..139393 + 237 Protein_143 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN29_RS25365 (DXN29_025270) 139448..139747 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / sul2 / floR / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / oqxA / oqxB - 1..238273 238273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146586 WP_000088046.1 NZ_CP047545:135092-136417 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146586 NZ_CP062763:c3597573-3597418 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146586 WP_024136327.1 NZ_CP047545:134794-135087 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146586 NZ_CP062763:3597585-3597643 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References