Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4510924..4511705 Replicon chromosome
Accession NZ_CP047544
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN29_RS22250 Protein ID WP_000626099.1
Coordinates 4510924..4511415 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN29_RS22255 Protein ID WP_001110452.1
Coordinates 4511412..4511705 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN29_RS22210 (4506110) 4506110..4506352 - 243 WP_197603740.1 hypothetical protein -
DXN29_RS22215 (4506349) 4506349..4506705 - 357 WP_033567083.1 hypothetical protein -
DXN29_RS22220 (4506702) 4506702..4507574 - 873 WP_033567082.1 ParA family protein -
DXN29_RS22225 (4507765) 4507765..4507842 - 78 Protein_4355 helix-turn-helix domain-containing protein -
DXN29_RS22230 (4507933) 4507933..4508265 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN29_RS22235 (4508337) 4508337..4508714 + 378 WP_000916345.1 EthD family reductase -
DXN29_RS22240 (4509747) 4509747..4509821 + 75 Protein_4358 porin family protein -
DXN29_RS22245 (4509924) 4509924..4510676 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN29_RS22250 (4510924) 4510924..4511415 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN29_RS22255 (4511412) 4511412..4511705 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN29_RS22260 (4512022) 4512022..4512243 + 222 WP_001576552.1 hypothetical protein -
DXN29_RS22265 (4512508) 4512508..4513383 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN29_RS22270 (4513380) 4513380..4513667 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN29_RS22275 (4513690) 4513690..4513905 + 216 WP_001595136.1 hypothetical protein -
DXN29_RS22280 (4513913) 4513913..4514182 + 270 WP_010989096.1 hypothetical protein -
DXN29_RS22285 (4514476) 4514476..4515381 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146583 WP_000626099.1 NZ_CP047544:c4511415-4510924 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146583 NZ_CP062763:2726855-2727133 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146583 WP_001110452.1 NZ_CP047544:c4511705-4511412 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146583 NZ_CP062763:2726662-2726853 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References