Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3564059..3564679 Replicon chromosome
Accession NZ_CP047544
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN29_RS17650 Protein ID WP_001280991.1
Coordinates 3564461..3564679 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN29_RS17645 Protein ID WP_000344807.1
Coordinates 3564059..3564433 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN29_RS17635 (3559198) 3559198..3560391 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DXN29_RS17640 (3560414) 3560414..3563563 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN29_RS17645 (3564059) 3564059..3564433 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN29_RS17650 (3564461) 3564461..3564679 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN29_RS17655 (3564858) 3564858..3565409 + 552 WP_001278792.1 maltose O-acetyltransferase -
DXN29_RS17660 (3565526) 3565526..3565996 + 471 WP_000136181.1 YlaC family protein -
DXN29_RS17665 (3566052) 3566052..3566192 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN29_RS17670 (3566198) 3566198..3566458 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN29_RS17675 (3566683) 3566683..3568233 + 1551 WP_000213139.1 EAL domain-containing protein -
DXN29_RS17685 (3568464) 3568464..3568853 + 390 WP_000961285.1 MGMT family protein -
DXN29_RS17690 (3568886) 3568886..3569455 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146577 WP_001280991.1 NZ_CP047544:3564461-3564679 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146577 NZ_CP062763:946472-946879 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146577 WP_000344807.1 NZ_CP047544:3564059-3564433 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146577 NZ_CP062763:946225-946491 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References