Detailed information of TA system TA146577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3564059..3564679
• Replicon: chromosome
• Accession: NZ_CP047544
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: DXN29_RS17650
• Protein ID: WP_001280991.1
• Coordinates: 3564461..3564679 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: DXN29_RS17645
• Protein ID: WP_000344807.1
• Coordinates: 3564059..3564433 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN29_RS17635 (3559198)	3559198..3560391	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DXN29_RS17640 (3560414)	3560414..3563563	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
DXN29_RS17645 (3564059)	3564059..3564433	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
DXN29_RS17650 (3564461)	3564461..3564679	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
DXN29_RS17655 (3564858)	3564858..3565409	+	552	WP_001278792.1	maltose O-acetyltransferase	-
DXN29_RS17660 (3565526)	3565526..3565996	+	471	WP_000136181.1	YlaC family protein	-
DXN29_RS17665 (3566052)	3566052..3566192	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
DXN29_RS17670 (3566198)	3566198..3566458	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
DXN29_RS17675 (3566683)	3566683..3568233	+	1551	WP_000213139.1	EAL domain-containing protein	-
DXN29_RS17685 (3568464)	3568464..3568853	+	390	WP_000961285.1	MGMT family protein	-
DXN29_RS17690 (3568886)	3568886..3569455	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T146577 WP_001280991.1 NZ_CP047544:3564461-3564679 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T146577 NZ_CP062763:946472-946879 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT146577 WP_000344807.1 NZ_CP047544:3564059-3564433 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT146577 NZ_CP062763:946225-946491 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0